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目的研究HLA抗原在肾移植供受者间的配合程度。方法采用微量淋巴细胞毒试验或分子生物学方法,分析915例肾移植供、受者的HLA配型情况。结果915例供受者的HLA抗原相配合程度为:在A抗原中,A1有11例(1.20%)、A2有280例(30.60%)、A3有8例(0.87%)、A11有138例(15.08%)、A24有108例(11.80%)、A26有5例(0.55%)、A19有90例(9.84%)及A28有3例(0.33%)。在B抗原中,B40有97例(10.60%)、B13有75例(8.20%)、B5有47例(5.14%)、B46有43例(4.70%)、B35有21例(2.30%)、B17有14例(1.53%)、B22有15例(1.64%)、B27有7例(0.77%)、B15有37例(4.04%)、B7有5例(0.55%)、B21有1例(0.11%)、B48有6例(0.66%)、B8有1例(0.11%)、B16有2例(0.22%)。在DR抗原中,DR1有2例(0.22%)、DR2有119例(13.01%)、DR17(3)有8例(0.87%)、DR4有42例(4.59%)、DR5有115例(12.57%)、DR6有31例(3.39%)、DR7有49例(5.36%)、DR8有16例(1.75%)、DR9有80例(8.74%)、DR10有2例(0.22%)。结论了解HLA抗原频率与肾移植供受者HLA抗原配合率的关系,有助于提高肾移植供受者的HLA配合率。
Objective To study the cooperation of HLA antigen between donor and recipient in renal transplantation. Methods The HLA matching of 915 renal transplant recipients and recipients was analyzed by using microlymph cytotoxicity test or molecular biology method. Results Among the 915 donors, 11 matched HLA antibodies were found in A1 antigen (1.20%) in A1, 280 (30.60%) in A2, 8 (0.87%) in A3 and 138 (15.08%), 108 (11.80%) in A24, 5 (0.55%) in A26, 90 (9.84%) in A19 and 3 (0.33%) in A28. Among the B antigens, 97 (10.60%) were B40, 75 (8.20%) were B13, 47 (5.14%) were B5, 43 (4.70%) were B46 and 21 (2.30% There were 14 (1.53%) B17, 15 (1.64%) B22, 7 (0.77%) B27, 37 (4.04%) B15, 5 (0.55%) B7 and 1 B21 0.11%), B48 in 6 cases (0.66%), B8 in 1 case (0.11%) and B16 in 2 cases (0.22%). Among the DR antigens, there are 2 cases (0.22%) of DR1, 119 cases (13.01%) of DR2, 8 cases (0.87%) of DR17 (3), 42 cases (4.59%) of DR4 and 115 cases (12.57 There were 31 cases (3.39%) in DR6, 49 cases (5.36%) in DR7, 16 cases (1.75%) in DR8, 80 cases (8.74%) in DR9 and 2 cases (0.22%) in DR10. Conclusion To understand the relationship between the frequency of HLA antigens and the HLA antigen co-morbidity of renal transplant recipients, and to improve the HLA matching rate of renal transplant recipients.