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从新的先导化合物６－氨基１，２－二苯乙烯－１出发，研究了１５个烷氨基１，２－二苯乙烯类钙调素拮抗剂的结构与活性之间的关系。发现：顺式构型的活性一般比反式构型强，而双键还原的化合物活性更低。从芳香亲脂中心到碱性中心之间的烷基链长度增加时，拮抗活性随之增强。ＱＳＡＲ分析显示：苯环上具较大脂水分配系数及给电子的取代基时拮抗活性可提高。
Starting from the new lead compound 6-aminostilbene-1, the relationship between structure and activity of 15 alkylamino stilbene antagonists was studied. It has been found that the cis configuration is generally more active than the trans configuration and the double bond reduced compound is less active. As the length of the alkyl chain increases from the aromatic lipophilic center to the basic center, the antagonistic activity increases accordingly. QSAR analysis showed that the antagonistic activity of benzene ring with larger lipid partition coefficient and electron donating substituents could be improved.