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近年来,妊高征患者血浆中6-酮-前列腺素 F_1α(PGI_2代谢产物)及血栓素 B_2(TxA_2代谢产物)的水平改变受到国内外学者注意。大多数研究表明,妊高征时孕妇血浆中6-Keto-PGF_1α减少和/或 TxB_2增加,提示妊高征发病可能与 PGI_2—TxA_2失衡有关。我们在严格控制观察病例的条件下,用放射免疫法测定了正常和中、重度妊高征孕妇外周血中6-Keto-PGF_1α和 TxB_2的含量,以揭示其在妊高征发病中的作用,现报告如下。
In recent years, the level of 6-keto-prostaglandin F_1α (PGI_2 metabolite) and thromboxane B_2 (TxA_2 metabolite) in patients with pregnancy induced hypertension (PIH) has been noticed by scholars at home and abroad. Most studies have shown that the reduction of 6-Keto-PGF_1α and / or TxB_2 in pregnant women during pregnancy-induced hypertension suggest that the pathogenesis of PIH may be related to the imbalance of PGI_2-TxA_2. In strict control of the observed cases, we measured the content of 6-Keto-PGF_1α and TxB_2 in the peripheral blood of normal and moderate-severe PIH pregnant women by radioimmunoassay to reveal its role in the pathogenesis of PIH. The report is as follows.