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本文比较研究了小鼠Ｓ１８０肉瘤表面对Ａｒ＋激光和Ｈｅ－Ｎｅ激光的漫反射率及注射光敏剂ＨｐＤ对漫反射率的影响。实验采用一套积分球系统及Ａｒ＋和Ｈｅ－Ｎｅ两种激光器的五种波长的激光（４７６．５ｎｍ、４８８．０ｎｍ、４９６．５ｎｍ、５１４．５ｎｍ、６３２．８ｎｍ），测定了注射光敏剂和没有注射光敏剂两组小鼠Ｓ１８０肉瘤表面的漫反射率。结果表明：注射光敏剂和没有注射光敏剂的小鼠肿瘤表面对六种激光的漫反射率无明显差异（Ｐ＞０．０５），提示在激光光动力学疗法中，计算实际进入肿瘤组织的光剂量时，可以不考虑ＨｐＤ的影响。肿瘤表面的激光漫反射率在５１４．５ｎｍ处有最小值，而在６３２．８ｎｍ处最大，说明波长５１４．５ｎｍ的Ａｒ＋激光在同样剂量下进入肿瘤组织的光能量要比６３２．８ｎｍ的激光大
In this paper, the effects of the diffuse reflectance of Ar+ laser and He-Ne laser on the surface of mouse S180 sarcoma and the effect of HpD on the diffuse reflectance of the injectable photosensitizer were compared. Experiments using an integrating sphere system and five wavelengths of laser (476.5nm, 488.0nm, 496.5nm, 514.5nm, 632.8nm) using Ar+ and He-Ne lasers were used to measure the injection of photosensitizers and The diffuse reflectance of the surface of S180 sarcoma in two groups of mice without injection of photosensitizer. The results showed that there was no significant difference in the diffuse reflectance of the six lasers on the tumor surface of mice injected with photosensitizer and no photosensitizer (P>0.05), suggesting that in laser photodynamic therapy, the actual entry into the tumor tissue was calculated. For light doses, the effect of HpD may not be considered. The diffuse reflectance of the tumor surface has a minimum value at 514.5 nm and a maximum at 632.8 nm, indicating that the Ar+ laser with a wavelength of 514.5 nm enters the tumor tissue at the same dose with a light energy greater than that of the 632.8 nm laser.