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目的:分析TAP、β_2-MG在新疆维吾尔族妇女子宫颈癌发生、发展中的作用及与发病年龄的关系,并初探其原因,为宫颈癌防治提供科学依据。方法:采用免疫组织化学方法检测维吾尔族31例宫颈炎组织及88例宫颈癌组织中TAP_1、TAP_2和β_2-MG蛋白的表达情况,并分为年轻组和中年组,进行细胞分化对比分析。结果:宫颈鳞癌TAP_1、TAP_2、β_2-MG阳性表达率(59.09%、68.18%、53.41%)显著低于宫颈炎组织(90.32%、100%、100%),P<0.05。宫颈癌组织中高、中、低分化鳞癌TAP_1阳性表达率(53.33%、53.06%、53.85%)明显低于原位癌组织(100%),中、低分化鳞癌β_2-MG阳性表达(46.94%、38.46%)低于原位癌(90.91%),P<0.05,且TAP_1与β_2-MG之间存在正相关(r=0.224,P<0.05),但宫颈癌组织中高、中、低分化鳞癌TAP_2阳性表达率(66.67%、65.31%、84.62%)与原位癌组织(68.18%)无关。其表达与年龄关系显示≤35岁组和>35岁组两个年龄组的原位癌与中分化鳞癌相比差异有统计学意义。结论:新疆维吾尔族宫颈癌患者发病年龄呈现年轻化趋势,TAP、β_2-MG蛋白低表达影响了MHC分子的正确组装及有效呈递抗原,致使癌细胞逃避机体免疫而致癌,其表达间的正相关关系及与细胞分化和发病年龄的关系说明TAP、β_2-MG蛋白可能与维吾尔族宫颈鳞癌的发生、发展,协同有关,从而为进一步阐明维吾尔族宫颈癌的致瘤机制奠定基础。
OBJECTIVE: To analyze the role of TAP and β_2-MG in the occurrence and development of cervical cancer in Xinjiang Uyghur women and its relationship with the age of onset, and to explore the reasons for this and provide a scientific basis for the prevention and treatment of cervical cancer. Methods: Immunohistochemical method was used to detect the expression of TAP_1, TAP_2 and β_2-MG in 31 cases of cervicitis and 88 cases of cervical cancer from Uygur nationality. The cells were divided into young group and middle-aged group. Results: The positive rates of TAP_1, TAP_2 and β_2-MG in cervical squamous cell carcinoma were significantly lower than those in cervicitis (59.09%, 68.18%, 53.41%, P <0.05). The positive expression rate of TAP_1 in high, moderate and poorly differentiated squamous cell carcinoma was significantly lower than that in situ carcinoma (53.33%, 53.06%, 53.85% %, 38.46%) were lower than that in situ carcinoma (90.91%), P <0.05, and there was a positive correlation between TAP_1 and β_2-MG (r = 0.224, The positive rate of TAP 2 in squamous cell carcinoma (66.67%, 65.31%, 84.62%) was not related to the carcinoma in situ (68.18%). The relationship between age and its expression in ≤35-year-old group and> 35-year-old group of two age groups of carcinoma in situ and differentiated squamous cell carcinoma compared with the difference was statistically significant. CONCLUSION: The age of onset of Uygur patients with cervical cancer in Xinjiang shows a tendency of younger age. The low expression of TAP and β_2-MG protein affects the correct assembly of MHC molecules and the effective presentation of antigens, resulting in the cancer cells escaping the body immunity and causing cancer. The positive correlation between them The relationship between TAP and β_2-MG protein may be related to the occurrence, development and synergy of Uigur cervical squamous cell carcinoma, which may provide a basis for further clarifying the tumorigenic mechanism of Uighur cervical cancer.