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目的 了解晚发性维生素K缺乏症患儿血清生化指标改变及其临床意义。方法 将42例晚发性维 生素K缺乏症患儿分为颅内出血组和非颅内出血组,测定血清总胆红素(T-BIL),直接胆红素(D-BIL),丙氨酸 氨基转移酶(ALT),门冬氨酸氨基转移酶(AST)γ-谷氨酰转移酶(GGT),总胆汁酸(TBA)等生化指标,并以18例 正常儿童为对照组进行比较分析。结果 42例患儿中有颅内出血24例,发生率54.3%。颅内出血组、非颅内出 血组和对照组T-BIL、D-BIL、GGT、TBA差异有显著意义,(F分别为36.69、65.90、19.10、20.39,均P<0.01 )。颅内出血组T-BIL、D-BIL、TBA明显高于非颅内出血组及对照组,差异有显著意义,均P<0.05。结论 血 清生化指标的测定对判断晚发性维生素K缺乏症患儿的病情的严重程度及预后有一定的临床意义。
Objective To understand the changes of serum biochemical indexes in children with late onset vitamin K deficiency and its clinical significance. Methods Twenty-two children with delayed vitamin K deficiency were divided into intracranial hemorrhage group and non-intracranial hemorrhage group. Serum levels of total bilirubin (T-BIL), direct bilirubin (D-BIL), alanine amino (ALT), aspartate aminotransferase (GGT) and total bile acid (TBA) were measured and compared in 18 normal children. Results In 42 cases, there were 24 cases of intracranial hemorrhage, the incidence rate was 54.3%. There were significant differences in T-BIL, D-BIL, GGT and TBA between intracranial hemorrhage group, non-intracranial hemorrhage group and control group (F = 36.69, 65.90, 19.10, 20.39, all P <0.01). The levels of T-BIL, D-BIL and TBA in intracranial hemorrhage group were significantly higher than those in non-intracranial hemorrhage group and control group (P <0.05). Conclusions The determination of serum biochemical indexes has some clinical significance for judging the severity and prognosis of children with late onset vitamin K deficiency.