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从恶性疟原虫基因组测序计划中不断获得的资料,为抗人体恶性疟的深入研究奠定了基础。了解基因序列是认识疟原虫诸如发育、传播、致病、抗药性等基本生物学过程以及鉴定新的药物和疫苗作用靶分子机制的关键。然而,即便是新近完成测序的恶性疟原虫3D7株,广泛认识这些基因及其在疟原虫生物学方面的作用仍非易事,况且,恶性疟原虫的基因组序列不仅是3D7株的序列,而是相同基因背景的恶性疟原虫变异序列的集合。因此,需要补救方法以确定遗传变异(即序列差异)和它们相应的功能之间的关系。 遗传作图可用于确定生物体有性重组中
The continuous availability of data from the Plasmodium falciparum genome sequencing project lays the foundation for an in-depth study of human falciparum malaria. Understanding the gene sequence is the key to understanding the basic biological processes of malaria parasites such as development, transmission, pathogenicity, resistance and other molecular mechanisms that identify new drug and vaccine targets. However, even recently sequenced Plasmodium falciparum 3D7 strains, it is not easy to gain a broad understanding of these genes and their role in the biology of Plasmodium Moreover, the genome sequence of Plasmodium falciparum is not only the sequence of the 3D7 strain but rather A collection of mutant sequences of Plasmodium falciparum of the same genetic background. Therefore, remedial approaches are needed to determine the relationship between genetic variations (ie, sequence differences) and their corresponding functions. Genetic mapping can be used to determine the organism’s sexual recombination