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胶质母细胞瘤Glioblastoma(GBM)可以分为原发性和继发性两型 ,原发性GBM的特征性分子遗传学改变是EGFR基因的扩增 ,而无染色体 1 7p上的杂合性丢失和 /或p53基因突变 ,继发性GBM的特征性分子遗传学改变是p53突变和 1 7p上的杂合性丢失 ,而无EGFR基因的扩增。GBM的发生与p53/MDM2 /p2 1通路和p1 6/p1 5/CDK4 /CDK6/Rb通路的异常有关。较高比例的GBM存在 1 0号、1 7号、9号、1 3号等染色体的分子遗传学异常。
Glioblastoma (GBM) can be divided into primary and secondary types. The characteristic molecular genetic changes of primary GBM are the amplification of EGFR gene without the heterozygosity on chromosome 17p Loss and / or p53 mutations, characteristic molecular genetic changes in secondary GBM are p53 mutations and loss of heterozygosity on 17p, without amplification of the EGFR gene. The occurrence of GBM is related to the abnormality of p53 / MDM2 / p2 1 pathway and p1 6 / p1 5 / CDK4 / CDK6 / Rb pathway. A higher percentage of GBMs have molecular genetic abnormalities such as chromosomes 10, 17, 9, and 13.