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目前,全球有超过100家实验室正在用不同的类器官模型开展包括肿瘤在内的其他疾病的研究,以探究类器官在药物筛选、抗肿瘤药物试验以及检测药物的敏感性和耐受性乃至疾病的成因。2009年,荷兰乌特勒支赫伯莱斯特研究所实验室的博士后汉斯·克莱夫(Hans Clevers,见图)展示了一个用于疾病研究的新模型:一个从成人干细胞衍生的可以复制小肠内衬细胞结构的三维类器官。不久前在接受《自然》杂志采访时,克莱夫就类器官应用前景作了如下描述。
At present, more than 100 laboratories around the world are using different organ-like models to conduct research on other diseases, including tumors, in order to explore the role of organoids in drug screening, antitumor drug testing and the detection of drug sensitivity and tolerability Cause of disease. In 2009, Hans Clevers, a postdoctoral fellow at the Hebrist Institute Laboratory in Utrecht, the Netherlands, showed a new model for disease research: one that can be derived from adult stem cells Reproduction of three-dimensional organs of the intestinal lining cell structure. Not long ago in an interview with “Nature” magazine, Clive on organ application prospects were described as follows.