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目的 :观察用人羊膜移植术治疗翼状胬肉、角膜热灼伤、化学伤、睑球粘连等眼表疾病的临床疗效。方法 :用人羊膜移植术治疗翼状胬肉 4 6例 6 5只眼 ,其中复发性翼状胬肉 16只眼 ,假性翼状胬肉 1只眼 ,角膜热灼伤、化学伤 3例 4只眼 ,睑球粘连 2例 2只眼 ,手术均在显微镜下完成。结果 :随访 3～ 11个月 ,羊膜移植手术均一次成功 ,无免疫排斥反应。翼状胬肉组 ,角膜透明 ,无新生血管 ,巩膜面结膜覆盖良好 ,充血消失 ;2只眼复发 ,复发率为 3 1% ,成功率 96 9%。 3例 (4只眼 )角膜热灼伤、化学伤者 ,术后均未见继续溶解、穿孔。睑球粘连者 ,结膜囊形成 ,睑球粘连松解 ,眼球活动基本正常。结论 :人羊膜移植是治疗翼状胬肉等眼表疾病较有效方法 ,它可抑制结膜下及角膜纤维化 ,促进结膜、角膜的上皮化。
Objective: To observe the clinical efficacy of artificial amniotic membrane transplantation in the treatment of ocular surface diseases such as pterygium, corneal thermal burns, chemical injuries and symblepharon. Methods: Amniotic membrane transplantation was used to treat 46 cases of 65 cases of pterygium, including 16 cases of recurrent pterygium, 1 case of pseudo-pterygium, 4 cases of corneal thermal burns, 3 cases of chemical injury, 4 cases of eyelid 2 cases of ball adhesion in 2 eyes, the surgery was completed under a microscope. Results: All cases were followed up for 3 to 11 months. Amniotic membrane transplantation was successful without any immune rejection. Pterygium group, corneal transparent, no neovascularization, scleral conjunctiva covered well, congestive disappear; 2 eyes recurrence, the recurrence rate was 31%, the success rate of 96 9%. 3 cases (4 eyes) corneal thermal burns, chemical wounded, no further dissolution after operation, perforation. Symposium, conjunctival sac formation, symblepharon release, the basic normal eye activity. Conclusion: Human amniotic membrane transplantation is an effective method for the treatment of ocular surface diseases such as pterygium, which can inhibit subconjunctival and corneal fibrosis and promote conjunctival and corneal epithelialization.