用ＲＰＨＰＬＣ方法研究了给家兔灌胃黄连素的吸收情况及药代动力学。结果表明，给家兔灌胃黄连素５０ｍｇ／ｋｇ，其血药浓度时间数据用３Ｐ８７药代动力学程序软件处理，经自动拟合，黄连素给家兔灌胃后的药代动力学模型符合一室开放模型，其主要药代动力学参数Ｔ（ｐｅａｋ）为（０６２±０２５）ｈ，Ｃ（ｍａｘ）为（９２７２±５０８９）μｇ／Ｌ，曲线下的面积ＡＵＣ值为（４９１７±２９５５）μｇ·ｈ／Ｌ。此结果表明，家兔口服黄连素后能被迅速吸收，且达到了有效的血药浓度 RP-HPLC method was used to study the rabbit absorption of berberine absorption and pharmacokinetics. The results showed that, given to rabbits berberine 50mg / kg, the plasma concentration-time data using 3P87 pharmacokinetic software, after automatic fitting, berberine given intragastric gavage pharmacokinetic model In accordance with the open-chamber model, the main pharmacokinetic parameters T (peak) were (062 ± 025) h and C (max) were (9272 ± 5089) μg / L, The area AUC value was 4917 ± 2955 μg · h / L. The results show that rabbits can be rapidly absorbed after oral berberine, and reached a valid plasma concentration