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在新生儿重症监护室,无创通气是治疗轻中度呼吸衰竭重要的呼吸管理技术,正确合理的应用可以有效避免有创呼吸机的使用及相应并发症的发生.近年研究发现,无创高频振荡通气(nHFOV)结合了经鼻持续气道正压通气(nCPAP)和高频通气(HFV)的优点,可以迅速改善氧合、有效清除二氧化碳,较好地改善呼吸衰竭,被认为是一类新型有效的无创通气模式.国际上对新生儿nHFOV技术的合理使用及有效性、安全性等进行了许多研究,取得了许多重要的经验和结果,该文就新生儿nHFOV的临床研究进展进行综述.“,”Noninvasive ventilation is an important respiratory management technique for the treatment of mild or moderate respiratory failure in the neonatal intensive care unit. Its reasonable application can effectively avoid the use of invasive ventilation and related complications. Recent studies have found that noninvasive high-frequency oscillatory ventilation has the advantages of both nasal continuous positive airway pressure and high-frequency ventilation and can rapidly improve oxygenation, effectively remove carbon dioxide, and improve respiratory failure. Therefore, it is considered a new and effective noninvasive ventilation mode. There are many studies on the rational use, efficacy, and safety of noninvasive high-frequency oscillatory ventilation in neonates around the world. This article reviews the advances in the clinical studies on noninvasive high-frequency oscillatory ventilation in neonates.