生物多糖冲洗胶液预防腹部手术后肠粘连的疗效分析

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目的:探讨医用生物多糖冲洗胶液(术泰舒)预防腹部手术后肠粘连的临床疗效及安全性。方法:选择衢州市中医医院2019年2月至10月收治的拟进行腹部手术的患者100例为观察对象。根据随机数字表法分为观察组(50例)和对照组(50例)。观察组和对照组在手术完毕关腹前分别采用术泰舒和0.9%氯化钠注射液冲洗腹腔及创面。观察患者术后胃肠功能恢复情况、肠粘连、腹痛及相关并发症的发生情况。结果:观察组的肠鸣音恢复时间[(28.81±5.56)h]、肛门排气[(36.34±6.24)h]和排便时间[(41.65±8.77)h]、下床行走时间[(3.78±0.64)d]比对照组[(32.75±5.15)h、(41.51±6.84)h、(48.05±9.81)h、(4.27±0.69)d]均显著缩短(n t=3.68、3.95、3.89、3.68,均n P<0.001);观察组术后 5 d、30 d肠粘连的发生率[10.0%(5/50)、12.0%(6/50)]较对照组[26.0%(13/50)、30.0%(15/50)]明显降低(χn 2=4.34、4.88,均n P<0.05);观察组术后并发症[26.0% (13/50)]总发生率显著低于对照组[54.0% (27/50)],差异有统计学意义(χn 2=8.17,n P<0.05);随着时间的延长,两组术后视觉模拟评分(VAS)评分均明显下降(n t=3.51、6.18,均n P<0.05)。与对照组比较,观察组术后1 d、3 d、5 d VAS评分均明显降低(n t=4.07、4.95、8.02,均n P<0.05)。n 结论:生物多糖冲洗胶液在腹部手术后肠粘连预防中具有较高的临床价值,有助于促进胃肠功能的恢复和早期功能锻炼,且无明显不良反应和并发症。“,”Objective:To investigate the clinical efficacy and safety of biopolysaccharide colloidal solution (Shutaishu) in the prevention of intestinal adhesion after abdominal surgery.Methods:A total of 100 patients scheduled to undergo abdominal surgery in Quzhou Municipal Hospital of Traditional Chinese Medicine from February to October in 2019 were included in this study. They were randomly divided into an observation group and a control group, with 50 patients in each group. Before closing the abdomen after surgery, abdominal cavity and wound were flashed with Shutaishu and 0.9% sodium chloride injection in the observation and control groups, respectively. The recovery of gastrointestinal function, intestinal adhesion, abdominal pain and the incidence of complications were compared between the observation and control groups.Results:The time to first regular bowel sound [(28.81 ± 5.56) h], time to first passage of flatus [(36.34 ± 6.24) h], time to first defecation [(41.65 ± 8.77) h], time taken for walking [(3.78 ± 0.64) d] in the observation group were significantly shorter than those in the control group [(32.75 ± 5.15) h, (41.51 ± 6.84) h, (48.05 ± 9.81) h, (4.27 ± 0.69) d,n t = 3.68, 3.95, 3.89, 3.68, all n P < 0.001]. At 5 and 30 days after surgery, the incidence of intestinal adhesion in the observation group [10.0% (5/50), 12.0% (6/50)] was significantly lower than that in the control group [26.0% (13/50), 30.0% (15/50), n χ2 = 4.34, 4.88, both n P < 0.05]. The total incidence of postoperative complications in the observation group was significantly lower than that in the control group [26.0% (13/50) n vs. 54.0% (27/50), n χ2 = 8.17, n P < 0.05]. With time, visual analogue scale score was significantly decreased in both groups ( n t = 3.51, 6.18, both n P < 0.05). At 1, 3 and 5 days after surgery, visual analogue scale score in the observation group was significantly lower than that in the control group ( n t = 4.07, 4.95 and 8.02, all n P < 0.05).n Conclusion:Biopolysaccharide colloidal solution is of high clinical value in the prevention of intestinal adhesion after abdominal surgery because it can promote the recovery of gastrointestinal function and early functional exercise, and has no obvious adverse reactions and complications.
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