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建立用HPLC测定蒿甲醚-羟丙基-β-环糊精包合物中蒿甲醚含量的方法。色谱柱为Lichrospher C18柱,乙腈-水(60:40,V/V)为流动相,检测波长210nm。包合物中蒿甲醚的含量在5—35μg范围内与峰面积呈线性关系(r=0.9998)。平均加样回收率为97.87%,RSD为0.66%(n=5)。
A method for the determination of artemether in artemether-hydroxypropyl-β-cyclodextrin inclusion complex by HPLC was established. The column was a Lichrospher C18 column. Acetonitrile-water (60:40, V / V) was used as the mobile phase and the detection wavelength was 210 nm. The inclusion compound artemether in the range of 5-35μg and the peak area was linear (r = 0.9998). The average recovery was 97.87% with a RSD of 0.66% (n = 5).