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Ki-1抗原是通过针对复发性霍奇金病(HD)病人胸腔积液中的细胞系的单克隆抗体(MoAb)所识别的。最初人们发现该抗体与Reed-Sternberg细胞及其变异型,以及在较少见的增生淋巴结滤泡间区的孤立免疫母细胞的抗原决定簇起反应,最近发现在一种弥漫性大细胞性淋巴瘤(DLCD)的一种亚型,即所谓Ki-1阳性(Ki-1~+)间变性大细胞淋巴瘤中常常有Ki-1抗原的表达。这种被Ki-1MoAb所确定的抗原是一种新的淋巴细胞激活的标记物称之为CD_(30)。本文报道对一组CD_(30)~+DLCL及HD病人比较分析的结果。
The Ki-1 antigen is recognized by a monoclonal antibody (MoAb) against a cell line in the pleural effusion of patients with relapsed Hodgkin disease (HD). Originally, this antibody was found to react with Reed-Sternberg cells and their variants, as well as with isolated antigenic determinants of isolated immunoblastic cells in the interfollicular zone of rare, proliferating lymph nodes, recently found in a diffuse large cell lymphoid One subtype of tumor (DLCD), the so-called Ki-1 positive (Ki-1~+) anaplastic large cell lymphoma, often has the expression of Ki-1 antigen. This antigen identified by Ki-1MoAb is a new marker of lymphocyte activation called CD_(30). This article reports the results of a comparative analysis of a group of CD_(30)~+DLCL and HD patients.