含有多个连续手性中心的结构单元常见于各种天然产物和人工合成的手性药物中,但由于异构体的数量随着手性中心的数目成指数上升,由此导致高选择性地合成含多个手性中心的单一异构体非常困难,一直以来是不对称催化研究领域最具挑战性的课题之一.中国科 Building blocks containing multiple contiguous chiral centers are common in various natural products and synthetic chiral drugs, but since the number of isomers increases exponentially with the number of chiral centers, thereby resulting in a highly selective synthesis Single isomers containing multiple chiral centers are very difficult and have long been one of the most challenging topics in the field of asymmetric catalysis.