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目的探讨ＩｇＭ肾病（ＩｇＭＮ）与微小病变肾病（ＭＣＮＳ）是否为同一性质疾病。方法对４０例成人ＩｇＭＮ与２０例ＭＣＮＳ进行临床、病理对比分析。结果ＩｇＭＮ血清ＩｇＭ水平较高，蛋白尿选择性低，肾上腺皮质激素治疗敏感性差，复发率高，治疗反应和病理损伤程度相关，其临床和病理表现存在显著差异。结论ＩｇＭＮ是一组区别于ＭＣＮＳ的独立性肾小球疾病。
Objective To investigate whether IgM nephropathy (IgMN) and minimal change nephropathy (MCNS) are the same or not. Methods 40 cases of adult IgMN and 20 cases of MCNS clinical and pathological comparative analysis. Results The serum level of IgM in IgMN was high, the proteinuria was low, the sensitivity of adrenal cortex hormones was poor, the relapse rate was high, and the response to treatment was related to the degree of pathological injury. The clinical and pathological manifestations of IgMN were significantly different. Conclusion IgMN is a group of independent glomerular diseases that are distinct from MCNS.