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目的探讨白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和神经生长因子(NGF)在慢性前列腺炎(CP)发病机制中的作用。方法162份前列腺标本取材于周围带,分别进行病理观察及IL-1β、TNF-α和NGF免疫组化分析。结果31.5%(51/162)的组织病理呈CP改变,其中轻度灶性间质炎44例,轻度灶性间质伴腺体周围炎5例,轻度灶性腺体周围炎2例。IL-1β、TNF-α和NGF在前列腺间质及上皮细胞中均有表达,在CP标本中的表达显著增加(P<0.01)。IL-1β和TNF-α之间的表达(r=0.797, P<0.01)、NGF和IL-1β(r=0.674,P<0.01)及TNF-α之间的表达(r=0.714,P<0.01)均存在正相关。结论CP的发病机制中可能存在神经免疫调节的参与,IL-1β、TNF-α和NGF可能参与了CP的神经免疫调节。
Objective To investigate the role of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and nerve growth factor (NGF) in the pathogenesis of chronic prostatitis (CP). Methods Totally 162 prostatic specimens were collected from the surrounding area. Pathological observation and immunohistochemical analysis of IL-1β, TNF-α and NGF were performed respectively. Results The pathological changes of 31.5% (51/162) showed CP, including 44 cases of mild focal interstitial inflammation, 5 cases of mild focal interstitial glandular inflammation and 2 cases of mild focal glandular inflammation . The expression of IL-1β, TNF-α and NGF in both stroma and epithelial cells of prostate were significantly increased in CP samples (P <0.01). (R = 0.797, P <0.01), the expression of NGF and IL-1β (r = 0.674, P <0.01) and the expression of TNF- 0.01) there is a positive correlation. Conclusion There may be neuroimmunoregulation in the pathogenesis of CP. IL-1β, TNF-α and NGF may be involved in the neuroimmunity regulation of CP.