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目的探讨米索前列醇(简称米索)用于晚期妊娠引产的安全有效剂量。方法回顾性分析我院在2001年3月至2005年5月间对150例有引产指征的单胎头位晚期妊娠产妇使用不同剂量米索引产的效果。结果A组(25μg次/)引产成功率89%(89/100),B组(50μg次/)引产成功率90%(45/50),两种剂量米索的促宫颈成熟及引产成功率差异无统计学意义,总产程及产后出血量差异均无统计学意义(P>0.05)。A组无一例宫缩过频,出现胎儿窘迫时能及时中转手术。B组出现宫缩过强4例、死产1例,羊水Ⅲ度发生率较高。结论米索前列醇为快速有效的促宫颈成熟及引产用药,引产成功率高,使用方便。安全、有效的剂量为25μg次/,最大剂量<100μg,50μg以上副作用增加。
Objective To investigate the safe and effective dose of misoprostol (misoprostol) for induction of labor during late pregnancy. Methods A retrospective analysis of our hospital in March 2001 to May 2005 between 150 cases of induction of labor indications of single-fetal head of late pregnancy maternal use of different doses of rice induced abortion. Results The success rate of induction of labor in group A (89 μg / g) was 89% (89/100), and that of group B (50 μg / ml) was 90% (45/50). Cervical maturation and induced labor success rate There was no significant difference between the two groups (P> 0.05). There was no significant difference in the total labor and the amount of postpartum hemorrhage (P> 0.05). A group without any contractions over frequency, fetal distress can appear timely transit surgery. In group B, there were 4 cases of uterine contractions, 1 case of stillbirth, and a higher incidence of Ⅲ degree amniotic fluid. Conclusion Misoprostol is a rapid and effective cervical ripening and induction of labor, high success rate of induction, easy to use. Safe, effective dose of 25μg times /, the maximum dose of <100μg, 50μg more side effects increased.