研究血管紧张素Ⅰ转化酶(ACE)基因插入/缺失(I/D)多态和中国汉族2型糖尿病患rn者视网膜病变(DR)的相关性。方法：用PCR技术检测102例2型糖尿病患者ACE基因I/D多态基因型结果：DR组与无DR组、病程5年无DR者(n=19)相比，D型等位基因和DD基因型的频率均无显著增高(P>0.05)。但增生DR组(n=17)较单纯DR组(n=20)D型等位基因和DD基因型的频率增高(x2分别为6.15、4.38，P0.05). D type allele and DD genotype distribution were also not prevalent in retinopathy patients with short duration(n=10)than those in non-retinopathy patients with long duration( n = 19, χ2 was 3.42,1.90 respectively, P > 0.05).But D type allele and DD genotype in proliferative group were higher than those in simple retinopathy group(χ2was 6.15,4.38 respectively, P < 0.05). Conclusion: It is suggested that simple retinopathy patients carrying D type allele are prior to proliferative pathological changes. It is available to determine ACE gene genotype in simple retinopathy patients for early prognosis and treatment of proliferative retinopathy .rn