论文部分内容阅读
目的:评价降浊定痛方联合小剂量秋水仙碱对痛风急性发作期患者的疗效。方法:将150例痛风患者随机分为治疗组(75例)与对照组(75例),分别口服降浊定痛方煎剂联合小剂量秋水仙碱及单药秋水仙碱,所有患者均口服碳酸氢钠片,疗程14天。观察患者症状严重程度积分、药物总有效率、血生化指标、以及血尿酸(BUA)、谷丙转氨酶(ALT)和血脂水平,并比较两药不良反应发生率。结果:与本组治疗前相比,两组症状严重程度积分均明显降低;两组药物总有效率无统计学差异;治疗2周后,两组患者血白细胞总数、中性粒细胞分类、血沉、CRP含量在治疗后均明显降低;但治疗组血尿酸、谷丙转氨酶、总胆固醇、甘油三脂显著降低,对照组在治疗后则无明显改善;与对照组比较,治疗组不良反应发生率率显著降低。结论:降浊定痛方联合小剂量秋水仙碱治疗对控制痛风患者急性期炎症状,疗效与秋水仙碱相当,但同时具有降血尿酸、降脂、保肝,安全性高的优点。
Objective: To evaluate the efficacy of Jiangzhuo Dingtong Recipe combined with low-dose colchicine on patients with acute gout. Methods: One hundred and fifty patients with gout were randomly divided into treatment group (75 cases) and control group (75 cases). The patients received oral administration of Jiangzhuadingtongfang decoction combined with low-dose colchicine and single-drug colchicine, all of which were orally Sodium bicarbonate tablets, treatment for 14 days. The symptom severity score, total drug efficacy, blood biochemical parameters, as well as the levels of BUA, ALT and blood lipid were observed. The incidences of adverse reactions were compared. Results: Compared with the group before treatment, the two groups of symptom severity points were significantly lower; the two groups of total effective rate was no significant difference; two weeks after treatment, the two groups of patients with total leukocyte count, neutrophil classification, ESR , CRP levels were significantly lower after treatment; but the treatment group serum uric acid, alanine aminotransferase, total cholesterol, triglyceride decreased significantly in the control group after treatment was no significant improvement; compared with the control group, the incidence of adverse reactions in the treatment group The rate is significantly lower. CONCLUSION: Jiangzhuo decoction combined with low-dose colchicine can control inflammation in acute phase of gout patients, and has the same curative effect as colchicine, meanwhile, it has the advantages of lowering blood uric acid, lowering blood fat, protecting liver and high safety.