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目的:观察力德希口服液对儿童高铅血症的临床疗效及其对儿童免疫功能的影响。方法:选择患高铅血症和轻度铅中毒儿童75例,随机分为两组,营养素组(A组)37例给予小儿善存片干预,力德希口服液组(B组)38例给予力德希口服液干预,疗程2个月。结果:临床干预后,A、B两组平均血铅含量和神经行为评分均下降,B组平均血铅含量的下降幅度明显大于A组(P<0.01);B组的IFN-γ升高,IL-4降低,IFN-γ/IL-4明显回升,与A组比较差异有统计学意义(P<0.05)。结论:力德希口服液能显著降低儿童血铅水平,改善高血铅儿童的神经行为,调节机体的免疫功能。
Objective: To observe the clinical efficacy of Lidexi oral liquid in children with hyperaemia and its effect on children’s immune function. Methods: Seventy-five children with hyperlipidemia and mild lead poisoning were randomly divided into two groups. 37 cases in nutrient group (group A) were treated with charcoal tablets and 38 cases in group Lidi oral liquid (group B) Give Lidex oral solution intervention, treatment for 2 months. Results: The mean blood lead and neurobehavioral scores of A and B groups decreased after the clinical intervention. The mean blood lead level decreased significantly in group B compared with group A (P <0.01) The level of IL-4 decreased and the level of IFN-γ / IL-4 increased significantly, which was significantly different from that of group A (P <0.05). Conclusion: Lidex oral liquid can significantly reduce children’s blood lead level, improve the blood lead children’s neurological behavior, regulate the body’s immune function.