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目的了解浦东新区吸毒人群梅毒和丙型肝炎病毒(HCV)的感染状况及影响因素,为制定预防干预措施提供科学依据。方法对浦东新区社区在管的吸毒人员进行梅毒和HCV血清学检测及问卷调查;用多因素Logistic回归模型分析该人群梅毒及HCV感染情况与高危行为的相关性。结果 420份问卷中,调查对象应答率为95.2%(400份)。400人中,梅毒螺旋体(TP)单阳性率12.3%(49人),TP双阳性率5.8%(23人),HCV阳性率44.0%(176人)。多因素分析结果显示,注射过毒品者TP双阳检出率是没有注射过毒品者的0.4倍[95%可信区间(CI):0.1~1.0];注射毒品者HCV阳性率是没有注射过毒品者的6.9倍(95%CI:3.9~12.1);共用针具者HCV检出率是没有共用过针具者的2.1倍(95%CI:1.1~3.8)。结论浦东新区吸毒人群的梅毒、HCV感染率较高,且与共用针具注射吸毒和不安全性行为有关,应积极开展针对性的干预措施,改变其危险行为。
Objective To understand the status of infection and influencing factors of syphilis and hepatitis C virus (HCV) among drug addicts in Pudong New Area and provide a scientific basis for the development of preventive interventions. Methods The syphilis and HCV serology tests and questionnaires were conducted among drug addicts in the community in Pudong New Area. The relationship between syphilis and HCV infection and high-risk behaviors was analyzed by multivariate Logistic regression model. Results Among the 420 questionnaires, the response rate was 95.2% (400). Among 400 people, the single positive rate of TP was 12.3% (49), the positive rate of TP was 5.8% (23), and the positive rate of HCV was 44.0% (176). Multivariate analysis showed that the detection rate of double positive tuberculosis (TP) in patients who had been injected with drugs was 0.4 times higher than those who did not (94% CI: 0.1-1.0). The positive rate of HCV in injecting drug was not injected (95% CI: 3.9-12.1). The detection rate of HCV among needle-sharing patients was 2.1 times (95% CI: 1.1-3.8) compared with those who did not share needles. Conclusion The syphilis population and HCV infection rate among drug users in Pudong New Area are high, and are related to injecting drug use and unsafe behavior of shared needles. Targeted interventions should be actively carried out to change their risk behaviors.