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目的探讨白藜芦醇(resveratrol,RES)减轻三氧化二砷对大鼠的毒性作用。方法腹腔注射三氧化二砷连续4周,治疗组在注射三氧化二砷前给予RES 30、60、120 mg·kg-1·d-1。4周后取动物血清、肝、肺、脾及脑组织测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、NO含量。结果与正常对照组相比,三氧化二砷引起动物血清、肝、肺、脾及脑组织NO和MDA水平显著增高,SOD和GSH-Px含量明显下降。RES治疗后显著改善三氧化二砷引起的上述变化,血清和肝、肺、脾及脑组织MDA、NO含量降低,而且总SOD、GSH-Px的活力均有明显升高,RES的作用呈剂量依赖性。结论RES可保护抗过氧化酶活性和抑制过氧化物产生。
Objective To investigate the toxic effects of resveratrol (RES) on arsenic trioxide in rats. Methods Intraperitoneal injection of arsenic trioxide was continued for 4 weeks. The treatment group received RES 30, 60, 120 mg·kg-1·d-1 before injection of arsenic trioxide. After 4 weeks, serum, liver, lung, spleen, and brain tissues were measured for superoxide Dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), NO content. Results Compared with the normal control group, arsenic trioxide caused significantly increased NO and MDA levels in serum, liver, lung, spleen, and brain tissues, and the SOD and GSH-Px levels decreased significantly. After treatment with RES, the above changes caused by arsenic trioxide were significantly improved. Serum and liver, lung, spleen, and brain tissues were reduced in MDA and NO, and the activities of total SOD and GSH-Px were significantly increased. The effect of RES was dose-dependent. Conclusion RES protects against peroxidase activity and inhibits peroxide production.