论文部分内容阅读
目的:研究我国宫颈癌高发区新疆维吾尔自治区维族妇女宫颈癌发病与人类乳头状瘤病毒(HPV)的关系。方法:采用聚合酶链反应(PCR)技术对南疆维族宫颈癌新鲜组织及正常宫颈组织(各40例)进行HPV-C、HPV16、HPV18及HPV6/11的检测。结果:HPV-C、HPV16、HPV18及HPV6/11在宫颈癌组织中的阳性率分别为87.5%、72.5%、10.0%及0%,在维族对照组中的阳性率分别为20.0%、5.0%、0及7.5%,在HPV-C阳性的宫颈癌中HPV16阳性占82.8%。宫颈癌组织中HPV-C及HPV16的阳性率明显高于正常对照组,差异有显著性(P<0.001)。HPV16在宫颈鳞癌组织中的阳性率明显高于腺癌,而HPV18在宫颈腺癌中的阳性率明显高于鳞癌,HPV总感染率及HPV16阳性率在宫颈癌的各临床分期及病理组织分级之间无显著性的差异。结论:HPV感染与我国宫颈癌高发区新疆南部地区维族宫颈癌发病有密切相关.其中HPV16感染在南疆维族妇女宫颈癌发病中起主要的作用,HPV16主要与鳞癌有关,而HPV18与宫颈腺癌有关。HPV-C及HPV16感染与宫颈癌临床分期及病理分级无关。
Objective: To study the relationship between the incidence of cervical cancer and the human papillomavirus (HPV) among Uighur women in Uygur Autonomous Region in China with high incidence of cervical cancer. Methods: HPV-C, HPV16, HPV18 and HPV6 / 11 were detected by polymerase chain reaction (PCR) in fresh tissues and normal cervical tissues of 40 Uygur women with cervical cancer in southern Xinjiang. Results: The positive rates of HPV-C, HPV16, HPV18 and HPV6 / 11 in cervical cancer tissues were 87.5%, 72.5%, 10.0% and 0% respectively. The positive rates in Uighur control group were 20.0%, 5.0% , 0 and 7.5%, HPV16 positive HPV-C-positive cervical cancer accounted for 82.8%. The positive rates of HPV-C and HPV16 in cervical cancer tissues were significantly higher than those in normal controls (P <0.001). The positive rate of HPV16 in cervical squamous cell carcinoma was significantly higher than that of adenocarcinoma, while the positive rate of HPV18 in cervical adenocarcinoma was significantly higher than that of squamous cell carcinoma. The total HPV infection rate and the positive rate of HPV16 in all clinical stages and pathological tissues There was no significant difference between grading. Conclusions: HPV infection is closely related to the occurrence of cervical cancer of Uygur in southern Xinjiang in the high incidence area of cervical cancer, HPV16 infection plays a major role in the occurrence of cervical cancer in Uighur women in southern Xinjiang, HPV16 is mainly associated with squamous cell carcinoma, Cancer related. HPV-C and HPV16 infection and cervical cancer stage and pathological grade has nothing to do.