目的　研究海洛因所致中毒性脑病的临床特点及影像学 (CT和MRI)特征。方法　对13例海洛因中毒性脑病患者的临床和影像学资料进行观察和分析。结果　 13例均为男性 ,均以烫吸海洛因为吸毒方式 ,9例是在毒品戒断过程中发病。主要临床表现为亚急性起病的弥漫性脑损害 ,尤以精神症状和小脑性共济失调为突出表现。 13例CT表现为脑内多发、广泛且明显对称性的低密度灶 ,累及双额、顶、颞、枕叶白质区及小脑半球齿状核和脑干 ,一般无占位征象。 6例同期MRI检查显示病灶的部位、范围与CT所见大致相同。结论　本病的诊断依靠明确烫吸海洛因史及具有特征性的临床表现和影像学征象。CT与MRI一样 ,对本病的诊断具有重要价值。激素对本病治疗效果差。 Objective To study the clinical features and imaging features of heroin-induced toxic encephalopathy (CT and MRI). Methods The clinical and imaging data of 13 cases of heroin toxic encephalopathy were observed and analyzed. Results All the 13 cases were male, all taking hot drugs for heroin abuse, and 9 cases were in the process of drug withdrawal. The main clinical manifestations of diffuse brain damage subacute onset, especially in the psychiatric symptoms and cerebellar ataxia as a prominent manifestation. 13 cases of CT showed multiple intracranial, extensive and obvious symmetry of low density lesions, involving double amount, top, temporal, occipital white matter and cerebellar dentate gyrus and brain stem, generally no placeholder signs. 6 cases of MRI examination at the same time showed the location of the lesion, the scope and CT see roughly the same. Conclusion The diagnosis of this disease depends on a clear hot heroin history and has the characteristics of clinical manifestations and imaging signs. CT, like MRI, is of great value in the diagnosis of this disease. Hormone treatment of this disease is poor.