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目的:探讨帕金森病(PD)患者运动并发症的临床特点及其影响因素。方法:详细记录作者单位6家医院107例帕金森病患者的病史资料,应用帕金森病评分量表(UPDRS)和Hoehn-Yahr(H-Y)进行评估,并进行统计分析、结果:①在107例PD患者中异动症的发生率为13.08%,症状波动为18.69%,两者在接受左旋多巴治疗5年以上患者中的发生率分别为30.0%、40.0%;②伴发运动并发症的患者与不伴运动并发症的患者相比较,其病程长,发病年龄小,服用左旋多巴每日剂量更大、时间更长,高血压发病率更低(P<0.05);③症状波动的独立影响因素有服用左旋多巴的疗程(OR=1.014,P<0.05)和多巴胺受体激动剂每日剂量(OR=1.018,P<0.05);异动症的独立影响因素有左旋多巴每日剂量(OR=1.013,P<0.05)。结论:帕金森病患者普遍伴运动并发症,其中服用大剂量左旋多巴、年轻起病、不伴高血压的患者更容易发生运动并发症;早期、持续、低剂量的多巴胺能刺激可以延缓运动并发症的发生。
Objective: To investigate the clinical characteristics and the influencing factors of motor complications in patients with Parkinson’s disease (PD). Methods: A total of 107 patients with Parkinson’s disease in 6 hospitals from the author’s hospital were enrolled in the study. The data of Parkinson’s Disease Rating Scale (UPDRS) and Hoehn-Yahr (HY) were used for statistical analysis. Results: The incidence of dyskinesia in PD patients was 13.08%, and the symptom fluctuation was 18.69%. The incidence of PD in patients receiving levodopa for more than 5 years was 30.0% and 40.0% respectively. The patients with movement complications Compared with patients without exercise complications, the course of the disease is longer, the age of onset is smaller, the daily dose of levodopa is more, the time is longer, the incidence of hypertension is lower (P <0.05); ③ the independence of the symptoms The influencing factors were the course of treatment with levodopa (OR = 1.014, P <0.05) and the daily dose of dopamine receptor agonist (OR = 1.018, P <0.05) (OR = 1.013, P <0.05). CONCLUSIONS: Parkinson’s disease is commonly associated with motor complications. Among them, high dose levodopa, young onset, and non-hypertensive patients are more likely to have motor complications. Early, sustained, low-dose dopaminergic stimulation can delay exercise Complications occur.