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目的探讨基质金属蛋白酶(MMP-9)在大肠癌中的表达及与患者预后的关系。方法应用SP免疫组织化学法检测MMP-9在120例原发性大肠癌患者中的表达。结果 MMP-9在大肠癌患者中的阳性表达率为46.7%(56/120);MMP-9的阳性表达率与淋巴结转移有关(P﹤0.05),有淋巴结转移组MMP-9的阳性表达率明显高于无淋巴结转移组(P=0.002),且随着Dukes’分期的加深,MMP-9的阳性表达率逐渐增高;MMP-9的表达与大肠癌患者的生存时间有关(P﹤0.05),MMP-9阳性表达的患者预后较差。结论 MMP-9的表达与淋巴结转移和生存时间有关。MMP-9可能为影响大肠癌患者预后的一个重要因素。
Objective To investigate the expression of matrix metalloproteinase (MMP-9) in colorectal carcinoma and its relationship with prognosis. Methods SP immunohistochemistry was used to detect the expression of MMP-9 in 120 patients with primary colorectal cancer. Results The positive rate of MMP-9 in colorectal cancer was 46.7% (56/120). The positive rate of MMP-9 was correlated with lymph node metastasis (P <0.05). The positive rate of MMP-9 in lymph node metastasis (P = 0.002). The positive expression rate of MMP-9 was gradually increased with the progress of Dukes’ staging. The expression of MMP-9 was related to the survival time of patients with colorectal cancer (P <0.05) , The positive expression of MMP-9 patients with poor prognosis. Conclusion The expression of MMP-9 is related to lymph node metastasis and survival time. MMP-9 may affect the prognosis of patients with colorectal cancer is an important factor.