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目的:探讨胰腺癌患者循环肿瘤细胞(CTC)中Toll样受体4(TLR4)、Toll样受体9(TLR9)、髓样分化因子88(myd88)的表达水平与患者化疗效果及转移、复发的关系。方法:将我院2015年6月-2016年6月收治并确诊的48例胰腺癌患者作为试验组,收集患者循环肿瘤细胞(CTC),检测其TLR4、TLR9、myd88信号表达情况,探讨其TLR4、TLR9、myd88信号表达水平与患者化疗效果及转移、复发的关系。结果:48例胰腺癌患者检出CTC 35例,检出率为72.9%。胰腺癌死亡、转移、复发患者TLR4、TLR9、myd88表达水平分别高于其存活、未转移、未复发患者,组间具有统计学差异(P<0.05)。胰腺癌化疗效果CR患者TLR4、TLR9、myd88表达水平显著低于其化疗效果PR、SD、PD患者,且四组间差异具有统计学意义(P<0.05);TLR4、TLR9、myd88表达水平与被膜受侵犯、淋巴结转移、肿瘤大小、CA199水平呈正相关(P<0.05)。结论:胰腺癌患者CTC中TLRs/myd88信号表达水平与患者化疗效果及转移、复发密切相关。
Objective: To investigate the expression of Toll-like receptor 4 (TLR4), Toll-like receptor 9 (TLR9), myeloid differentiation factor 88 (myd88) in patients with pancreatic cancer and the effect of chemotherapy, metastasis and recurrence Relationship. Methods: Forty-eight patients with pancreatic cancer who were admitted to our hospital from June 2015 to June 2016 were selected as the experimental group. The circulating tumor cells (CTCs) were collected and the expression of TLR4, TLR9 and myd88 were detected. The TLR4 , TLR9, myd88 signal expression in patients with chemotherapy and metastasis, relapse. Results: CTA was detected in 48 cases of pancreatic cancer in 35 cases, the detection rate was 72.9%. The expression of TLR4, TLR9 and myd88 in patients with death, metastasis and recurrence of pancreatic cancer were significantly higher than those in patients with non-metastasis and non-recurrence, respectively (P <0.05). The expression of TLR4, TLR9 and myd88 in CR patients with pancreatic cancer was significantly lower than that in PR, SD and PD patients (P <0.05). The expression of TLR4, Invasion, lymph node metastasis, tumor size, CA199 level was positively correlated (P <0.05). Conclusion: The expression of TLRs / myd88 in CTC of patients with pancreatic cancer is closely related to the effect of chemotherapy, metastasis and recurrence.