论文部分内容阅读
低氧条件下,人体某些组织和器官可发生纤维化改变,导致其功能受损,甚至丧失,在这个过程中,转化生长因子β(Transforming growth factor-beta,TGF-β)一直被认为是致纤维化关键的细胞因子,它除致纤维化作用外,还有抗炎、抗肿瘤及抑制免疫等生物学效应,但是单纯干扰TGF-β的正面效应限制了抗TGF-β抗体的应用,可能引起许多难以预料的不良反应。而结缔组织生长因子(connective tissuegrowth factor,CTGF)是近年来新发现的TGF-β下游的一个信号介质,主要介导TGF-β的促细胞增生和细胞外基质合成,掌握TGF-β及其CTGF的促纤维化机制及其与低氧的调节关系,为应用TGF及CTGF的抑制剂及其抗体等抗纤维化治疗提供更好的依据。
In hypoxia, certain tissues and organs of the human body may undergo fibrosis changes, resulting in impaired or even loss of function. In the process, Transforming growth factor-beta (TGF-β) has been considered as In addition to the role of fibrosis, it also has the biological effects of anti-inflammatory, anti-tumor and immune suppression. However, the positive effect of simply interfering with TGF-β limits the application of anti-TGF-β antibody, May cause a lot of unpredictable adverse reactions. The connective tissue growth factor (CTGF) is a newly discovered signal transduction medium downstream of TGF-β in recent years. It mainly mediates the proliferation and extracellular matrix synthesis of TGF-β, Fibrosis mechanism and its relationship with hypoxia regulation for the application of TGF and CTGF inhibitors and antibodies such as anti-fibrosis treatment to provide a better basis.