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[目的]探讨促性腺激素释放激素类似物(GnRHa)联合左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫腺肌病(AM)的临床疗效。[方法]将70例AM患者随机分为观察组(n=34,GnRHa联合LNG-IUS治疗)与对照组(n=36,采用LNG-IUS治疗),比较两组患者治疗后子宫体积、痛经程度及月经过多等症状的改善情况。[结果]治疗后,子宫体积、痛经程度评分及月经量观察组明显低于或少于对照组,差异有统计学意义(P<0.05);对照组随访期间共出现7例(20.58%)阴道流血淋漓不尽,4例(11.76%)发生脱环;观察组则无阴道流血淋漓不尽情况及脱环发生。[结论]GnRHa联合LNG-IUS治疗与单纯放置LNG-IUS治疗相比,可以更有效治疗AM,缓解临床症状。
[Objective] To investigate the clinical efficacy of GnRHa combined with levonorgestrel intrauterine release system (LNG-IUS) in the treatment of adenomyosis (AM). [Methods] Seventy patients with AM were randomly divided into observation group (n = 34, GnRHa combined with LNG-IUS treatment) and control group (n = 36, LNG-IUS treatment) Degree and menorrhagia and other symptoms of improvement. [Results] After treatment, uterine volume, dysmenorrhea score and menstrual flow observation group were significantly lower than or less than the control group, the difference was statistically significant (P <0.05); in the control group, there were 7 cases (20.58%) of vagina Bleeding dripping, 4 cases (11.76%) de-loop; the observation group was vaginal bleeding dripping endless situation and de-loop occurred. [Conclusion] Compared with LNG-IUS alone, GnRHa combined with LNG-IUS can treat AM more effectively and relieve clinical symptoms.