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目的：探讨肿瘤患者细胞免疫功能的变化及其临床意义。方法：应用流式细胞仪间接免疫荧光染色检测法检测了121例肿瘤患者和110名正常人的外周血T淋巴细胞亚群的分布及天然杀伤细胞（NK细胞）活性，并进行对比分析。结果：肿瘤患者外周血T淋巴细胞表面分化抗原（分化群，CD）中的CD3＋、CD4＋和NK细胞的CD（16＋56）＋比正常人显著降低（P ＜0．05），CD8＋比正常人显著升高（P ＜0．05），CD4＋／CD8＋比值比正常人明显下降（P ＜0．05）。结论：肿瘤患者的细胞免疫功能严重受损；上述指标可作为肿瘤的免疫诊断和监测指标。
Objective: To investigate the changes and clinical significance of cellular immune function in patients with cancer. Methods: The distribution of peripheral blood T lymphocyte subsets and the activity of natural killer cells (NK cells) in 121 patients with tumor and 110 normal controls were detected by flow cytometry indirect immunofluorescence assay and compared. RESULTS: CD3+, CD4+, and NK cells in peripheral blood T lymphocyte differentiation antigens (differentiated group, CD) were significantly lower in tumor patients than in normal controls (P < 0.05). CD8+ was significantly greater than normal. Elevated (P <0.05), CD4 + / CD8 + ratio was significantly lower than normal (P <0.05). Conclusion: The cellular immune function of cancer patients is seriously impaired; the above indicators can be used as an immune diagnosis and monitoring index of tumors.