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目的 探讨白介素21(interleukin-21,IL-21)及IL-22在木村病(Kimura’s disease)中的表达及意义.方法 通过免疫组化SP法检测36例木村病(木村病组)和7例非木村病对照者(对照组)中IL-21及IL-22的表达,利用Image Pro Plus 6.0软件测定两组IL-21及IL-22的积分吸光度值(integrated absorbance,IA)并进行比较;收集所有木村病患者性别(男、女)、年龄(＜35岁、≥35岁)、发病部位(单侧、双侧)及肿物最大直径(＜3.5 cm、≥3.5 cm)、累及部位(较多、较少)、局部瘙痒情况(有、无)、血嗜酸性粒细胞百分比(高、低)和随访结果(复发、未复发)等临床信息,分析IL-21、IL-22在上述临床指标各亚组间的表达差异.结果 木村病患者IL-21 IA[M(Q)]为1 373 418(1 800 926),IL-22IA[M(Q)]为462 086(484 672),均显著高于对照组[IL-21、IL-22IA分别为70 445(44 658)、51 599(71 241),P＜0.05].36例木村病患者IL-21的表达中,无瘙痒组及无复发组分别显著高于瘙痒组及复发组(Z=-1.993,P＜0.05;Z=-2.303,P＜0.05);IL-22的表达中,受累部位数较多组及高嗜酸性粒细胞组显著高于受累部位数较少及低嗜酸性粒细胞组(Z=-1.979,P＜0.05;Z=-2.025,P＜0.05).性别、年龄、发病部位及肿物最大直径各亚组间IL-21及IL-22的表达差异均无统计学意义(P＞0.05).结论 IL-21及IL-22参与木村病的发病过程,其表达与木村病的致病机制可能有密切关系.“,”Objective To investigate the expressions of interleukin(IL)-21(IL-21) and IL-22 in patients with Kimura’s disease(KD).Methods Expressions of IL-21 and IL-22 were examined immunohistochemically in 36 patients with KD and 7 normal controls.The integral absorbance(IA) of the two groups was compared.Meanwhile, clinical data were reviewed.Results The IA of IL-21[M(Q): 1 373 418 (1 800 926)] and IL-22[M(Q): 462 086(484 672)] in KD was significantly higher than those in normal controls[M(Q): 70 445(44 658), 51 599(71 241), P＜0.05].The overexpression of IL-21 was significantly associated with pruritus(Z=-1.993, P＜0.05).Moreover, IL-21 was identified for disease recurrence(Z=-2.303,P＜0.05).There was a significant association between the expression of IL-22 and the number of affected sites (Z=-1.979, P＜0.05).In addition, IL-22 was significantly higher in the high-eosinophils group than in the low-eosinophils group(Z=-2.025, P＜0.05).There was no association between IL-21, IL-22 and age,gender, laterality, maximum size.Conclusions IL-21 and IL-22 may be involved in the pathogenesis of KD.