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高分子试剂的应用,可以回溯到三十年代中期,以缩聚法制得离子交换树脂作为起点.之后,在1944年又制得以苯乙烯-二乙烯基苯为母体的离子交换树脂和电子交换树脂,1951年又将生物酶固定在高聚物上.但直到1963年梅里菲尔德(Merrifield)成功地在高聚物载体上进行了肽的固相合成之后,高聚物负载反应的优点才充分被认识.近年来这方面的研究报告迅猛增加,专题介绍和综述文章也屡屡发表,高分子试剂的研究在国际上受到极大的重视.
The application of polymer reagents can be traced back to the mid-1930s, the polycondensation system made of ion exchange resin as a starting point, then in 1944 was made with styrene - divinylbenzene as the parent ion exchange resin and the electron exchange resin, The enzyme was immobilized to the polymer in 1951. However, the merits of the polymer loading reaction were not fully recognized until Merrifield succeeded in the solid-phase synthesis of the peptide on the polymer carrier in 1963 In recent years, research reports in this area have been increasing rapidly, and presentations and review articles have also been published frequently, and the research on polymer reagents has drawn great attention in the world.