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在正常情況下,各种食物的物理和化学因素,胃液中胃酸和胃蛋白酶的消化作用,均不能损伤胃粘膜;这是由于正常的胃粘膜具有一系列防御机能,包括胃粘膜分泌粘稠的粘液,胃粘膜屏障、粘膜细胞旺盛的更新能力、碱性胰液和十二指肠液的中和胃酸作用,肠抑胃泌素的分泌、以及十二指肠正常的排空功能;尤其是胃壁丰富的血液供应,胃粘膜合成释放内源性PGs的功能、以及适应性细胞保护作用的新发现。在神经内分泌调节下,攻击因素和防御因素处于动态平衡。本文就近年来胃粘膜血流量(GMBF)和前列腺素(PGs)及氧自由基(FOR)在消化道疾病中的研究作一简述。一、胃粘膜血流量与疾病陶志达等人曾对14例尸体胃标本的血管注射造影
Under normal circumstances, the physical and chemical factors of various foods, stomach acid and pepsin digestion, can not damage the gastric mucosa; this is because the normal gastric mucosa has a series of defense functions, including the mucous secretion of the gastric mucosa. Mucus, gastric mucosal barrier, rejuvenating ability of mucosal cells, neutralizing gastric acid effects of alkaline pancreatic juice and duodenal fluid, intestinal gastrin secretion, and normal emptying function of duodenum; especially rich stomach wall The blood supply, the function of the gastric mucosa to synthesize endogenous PGs, and new discoveries of adaptive cell protection. Under neuroendocrine regulation, attack and defense factors are in dynamic equilibrium. In this paper, the recent studies on gastric mucosal blood flow (GMBF), prostaglandins (PGs) and oxygen free radicals (FOR) in digestive tract diseases are briefly described. I. Gastric Mucosal Blood Flow and Diseases Tao Zhida et al. Vascular injection of 14 cadaver stomach specimens.