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目的:分析巨幼细胞性贫血脾肿大的超声表现及临床结果的相关性。方法:①选择2008年至2011年在哈尔滨医科大学第二临床医院血液内科住院的巨幼细胞性贫血患者239例。②按贫血程度将患者设为重度贫血组108例(血红蛋白>30 g/L);中度贫血组78例(血红蛋白>60 g/L);轻度贫血组53例(血红蛋白>90 g/L)。③超声检查显示脾厚度超过4 cm或长度超过8 cm,最大长径超过11 cm以及左肋缘下探及脾,均可判定为脾大。④率的资料比较采用卡方检验,相关性分析采用Pearson相关。结果:对不同贫血程度的脾大发生率进行比较分析,采用卡方检验(x2=22.873,P<0.01)。贫血程度与脾大进行Pearson相关性分析(r=0.309,P<0.01)。结论:①巨幼细胞性贫血可导致脾肿大。②脾大与贫血程度有关系。
OBJECTIVE: To analyze the correlation between the ultrasound findings and clinical outcome of megaloblastic anemia splenomegaly. Methods: (1) 239 megaloblastic anemia patients admitted to Department of Hematology, Second Hospital of Harbin Medical University from 2008 to 2011 were selected. According to the degree of anemia, the patients were divided into severe anemia group (hemoglobin> 30 g / L), moderate anemia group (hemoglobin> 60 g / L), mild anemia group ). ③ ultrasonography showed that the spleen thickness of more than 4 cm or length of more than 8 cm, the largest diameter of more than 11 cm and the left rib margin exploration and spleen, can be judged as splenomegaly. ④ Rate data were compared using chi-square test, correlation analysis using Pearson correlation. Results: The incidence of splenomegaly with different degree of anemia was compared and analyzed by chi-square test (x2 = 22.873, P <0.01). Pearson correlation analysis between anemia and splenomegaly (r = 0.309, P <0.01). Conclusion: ① Megaloblastic anemia can lead to splenomegaly. ② splenomegaly and the relationship between the degree of anemia.