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目前国内制造片剂用的辅料绝大部分仍为淀粉、糊精、糖粉等,不但耗用大量粮食,且成品在贮藏期间,特别在湿度较高的地区易产生回软变质甚至发霉等现象。硫酸钙为一种无机盐,性质稳定,且有较好的抗潮性能,与多种药物配伍后不起作用。人工合成的硫酸钙,通常为含有两分子结晶水的二水物(CaSO_4·2H2O),在升温条件下会逐步失水。若消失结晶水达一分子以上时,遇水会出现不同程度的固化现象。失去一个半结晶水的半
At present, most of the excipients used in the manufacture of tablets in China are still starch, dextrin and powdered sugar, which not only consume a large amount of food, but also produce the phenomenon of softening or mildew during storage, especially in the areas with high humidity . Calcium sulfate is an inorganic salt, stable in nature, and has good moisture resistance, with a variety of drugs does not work after compatibility. Synthetic calcium sulphate, usually a dihydrate (CaSO 4 · 2H 2 O) containing two molecules of water of crystallization, will gradually lose water at elevated temperatures. If the disappearance of crystal water up to more than one molecule, the water will appear to varying degrees of curing phenomenon. Lose half of a semi-crystalline water