采用正交试验法,对茵山莲颗粒的水提取工艺进行优化。采用正交表L9 (34),以煎煮次数、加水倍数、煎煮时间为因素,以高效液相色谱法测定茵陈中绿原酸的含量为指标进行试验。结果表明优选工艺可行,含量测定方法准确可行,为改制剂质量保证提供了依据。 Orthogonal test method was used to optimize the water extraction process of Yin mountain lotus granules. Orthogonal table L9 (34) was used to determine the content of chlorogenic acid in Herba Artemisiae as an index by the factors such as the times of boiling, the times of adding water and the boiling time. The results show that the optimal process is feasible and the content determination method is accurate and feasible, which provides the basis for the quality assurance of the preparation.