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项目简介:DAST是一种亲核氟化试剂,应用较为广泛,通常作为药物的氟化试剂。它能方便的实现官能团的转换,从而引入氟原子。如:与醇反应得到相应的氟代烷;与酰氯化合物反应得到相应的酰氟;与醛或酮反应得到偕二氟化合物;与亚砜反应得到α-氟代硫醚,再用过氯苯甲酸氧化,得到α-氟代亚砜等。本技术制备工艺先进,成本低,拥有自主知识产
Project Description: DAST is a nucleophilic fluorination reagent, widely used, usually as a fluorinating reagent for drugs. It can facilitate the conversion of functional groups to introduce fluorine atoms. Such as: with the alcohol to give the corresponding fluoroalkane; with the acid chloride compound to give the corresponding acid fluoride; with aldehydes or ketones to get geminal difluoride compounds; and sulfoxide reaction of α-fluorothioether, then chlorobenzene Oxidation of formic acid gives α-fluorosulfoxides and the like. The preparation of advanced technology, low cost, with independent intellectual property