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目的探讨早期胰岛素强化治疗对新诊断2型糖尿病(T2DM)患者转归的影响。方法 158例新诊断T2DM患者,随机分为观察组和对照组,每组79例。观察组采用胰岛素强化治疗,对照组给予常规降糖药物治疗,比较两组患者治疗前后三酰甘油(TG)、总胆固醇(TC)、体质量指数(BMI)、血糖水平及空腹、餐后C肽水平,观察两组患者治疗后1年病情转归情况。结果观察组治疗后TG、TC、BMI、血糖水平及空腹、餐后C肽水平与对照组比较,差异均具有统计学意义(P<0.05或<0.01);观察组治疗后1年病情转归情况明显优于对照组,差异有统计学意义(P<0.05)。结论早期给予胰岛素强化治疗对新诊断T2DM患者胰岛β细胞功能有显著改善作用,并对患者病情转归有益,疗效明显优于常规降糖药物。
Objective To investigate the effect of early insulin therapy on the outcome of newly diagnosed type 2 diabetes mellitus (T2DM). Methods A total of 158 newly diagnosed T2DM patients were randomly divided into observation group and control group, 79 cases in each group. The patients in the observation group were treated with intensive insulin therapy and the control group were given conventional antidiabetic drugs. The triglyceride (TG), total cholesterol (TC), body mass index (BMI), blood glucose and fasting, postprandial C Peptide levels, the two groups were observed after 1 year of treatment outcome. Results The levels of TG, TC, BMI, blood sugar, fasting and postprandial C-peptide levels in the observation group were significantly different from those in the control group (P <0.05 or <0.01) The situation was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusions Early intensive insulin therapy can significantly improve pancreatic β-cell function in patients with newly diagnosed T2DM, and is beneficial to patients’ condition. The curative effect is obviously better than that of conventional hypoglycemic drugs.