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目的：探讨丙型肝炎病毒（ＨＣＶ）基因型与干扰素治疗后ＨＣＶＲＮＡ阴转远期效果的相关性．方法：采用反转录ＰＣＲ（ＲＴ－ＰＣＲ）方法．结果：干扰素治疗后，经过１８ｍｏ～２６ｍｏ的随访，Ⅱ／１ｂ型ＨＣＶＲＮＡ持续阴转率为２０．０％（４／２０）；Ⅲ／２ａ型为７０．０％（７／１０），两型疗效相差非常显著（Ｐ＜０．０１）．结论：干扰素治疗丙型肝炎的疗效与丙型肝炎病毒基因型有关，对Ⅲ／２ａ型的疗效优于Ⅱ／１ｂ．
Objective: To investigate the relationship between hepatitis C virus (HCV) genotypes and long-term effect of HCV RNA on long-term HCV RNA after interferon treatment. Methods: Reverse transcription PCR (RT-PCR) was used. Results: After 18 months to 26 months of follow-up, the continuous negative conversion rate of type Ⅱ / 1b HCVRNA was 20.0% (4/20) and that of type Ⅲ / 2a was 70.0% (7/10) Type effect difference is very significant (P <0.01). Conclusion: The efficacy of interferon in the treatment of hepatitis C is related to the genotype of hepatitis C virus, and its effect on type Ⅲ / 2a is better than that of type Ⅱ / 1b.