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目的 研究门静脉高压犬失血性休克时不同静脉灌注量对血流动力学的影响。方法 行缩窄门静脉主干1/2加丝线慢性栓塞术建立犬肝前性门静脉高压症模型,2周后股动脉快速放血制失血性休克模型,分大剂量、小剂量组静脉灌注复苏休克,观察不同静脉灌注量对门静脉高压失血性休克犬血流动力学的影响。结果 肝前性门静脉高压犬在失血性休克期血流动力学发生一系列改变,加重门静脉高压症时存在的血流动力学紊乱。快速静脉灌注复苏休克后,平均动脉压（MAP）、下腔静脉压（IVCP）、门静脉压（PVP）、门静脉压力梯度（PVPG）、门静脉血流量（PVBF）、肝动脉血流量（HABF）及肝血流量（HBF）均迅速上升,大剂量静脉灌注组升高幅度均较小剂量静脉灌注组大。PVR、SVR、HAR均显著降低。大剂量静脉灌注复苏休克,PVP、PVPG、PVBF、HABF、HBF出现反跳式升高,超过基线水平PVA达（3.28±0.34）kPa。而小剂量静脉灌注复苏休克时PVPG、PVP、PVBF、HABF、HBF与MAP、IVCP改变大致平行,无此反跳式升高,PVP至（2.34±0.26）kPa。大剂量静脉灌往组PVPG较PVP升高更早,更显著,并且超过基础值的 13％,达（2.58±0.37）kPa,故其发生再出血的危险性大为增加。小剂量静脉灌柱组PVPG一直低于基线水平,而且较基础值降低22％以上,至（1.67±0.27）
Objective To study the hemodynamic effects of different intravenous perfusion on hemorrhagic shock in patients with portal hypertension. Methods The canine model of prehypertensive portal hypertension was established by narrowing the main vein of the portal vein 1/2 and the chronic embolization of silk thread. After 2 weeks, the model of hemorrhagic shock of the femoral artery was rapidly exsanguinated. The rats in the high and low dose groups received intravenous infusion of resuscitation shock. Effect of Different Intravenous Dosage on Hemodynamics of Hemorrhagic Shock in Portal Hypertensive. Results The prehypertensive portal hypertension in dogs during hemorrhagic shock hemodynamics a series of changes, aggravating the hemodynamic disturbance of portal hypertension. MAP, IVCP, PVP, PVPG, PVBF and HABF after rapid intravenous infusion of resuscitation shock were measured. Hepatic blood flow (HBF) were rapidly increased, high-dose intravenous infusion group were higher than the small dose intravenous infusion group. PVR, SVR, HAR were significantly reduced. High dose intravenous infusion of shock, PVP, PVPG, PVBF, HABF, HBF rebound increased over the baseline level of PVA (3.28 ± 0.34) kPa. However, PVPG, PVP, PVBF, HABF, HBF and MAP and IVCP were almost parallel in low-dose intravenous infusion of resuscitation shock, with no rebound increase and PVP to (2.34 ± 0.26) kPa. Compared with the PVP, the PVPG in the high dose intravenous infusion group was earlier and more significant than the PVP, and exceeded the base value of 13%, reaching (2.58 ± 0.37) kPa, so the risk of rebleeding greatly increased. The PVPG in the low-dose intravenous infusion group was always lower than the baseline level, and was lower than the baseline by more than 22% to (1.67 ± 0.27)