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[目的]探讨原发于睾丸和纵隔生殖细胞恶性肿瘤的临床特征、生存率及预后影响因素。[方法]回顾性分析1990至2000年收治的22例原发于睾丸和19例原发于纵隔的生殖细胞肿瘤患者的临床资料,以无疾病进展时间和总生存率为主要观察目标,进行预后评估。[结果]睾丸和纵隔生殖细胞肿瘤患者无疾病进展时间分别为62个月和19个月,10年总生存率分别为60.0%和13.3%(P=0.019)。Cox比例风险模型多因素分析结果显示:病理类型和临床分期是影响预后的主要因素。[结论]睾丸生殖细胞瘤患者的预后明显高于纵隔生殖细胞瘤患者,需要进一步探讨如何提高纵隔生殖细胞瘤的治疗效果。
[Objective] To investigate the clinical features, survival rate and prognostic factors of primary malignant tumors in testis and mediastinum. [Methods] The clinical data of 22 patients with germ cell tumors originating in the testis and 19 patients with primary septal germ cell tumors admitted from 1990 to 2000 were retrospectively analyzed. The progression-free time and overall survival were taken as the main targets for prognosis Evaluation. [Results] The progression-free time of testicular and mediastinal germ cell tumors was 62 months and 19 months respectively. The 10-year overall survival rates were 60.0% and 13.3%, respectively (P = 0.019). Cox proportional hazards model multivariate analysis showed that: pathological type and clinical stage are the main factors that affect the prognosis. [Conclusion] The prognosis of patients with testicular germ cell tumor is significantly higher than that of patients with mediastinal germ cell tumor, and it is necessary to further explore how to improve the therapeutic effect of mediastinal germ cell tumor.