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在糖尿病肾病的进展中 ,TGF β作为一关键性的细胞因子介导糖尿病诱生的系膜区基质沉积 ,这一事实无庸质疑 ;TGF β导致的肾小球硬化、肾动脉玻璃样变性、小管间质纤维化也不必赘述。现仅就几个较新颖的信号传导途径对TGF β如何发挥其上述病理效应简述如下。1 TGF β诱导基质
The fact that TGFβ acts as a key cytokine mediates the deposition of diabetes-induced mesangial stroma in the development of diabetic nephropathy is undeniable; TGFβ-induced glomerulosclerosis, renal arteriolar vitreous degeneration, Interstitial fibrosis also needless to say. The pathological effects of TGF [beta] on these pathways are described below with respect to only a few of the more novel signaling pathways. 1 TGF β induction matrix