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目的:探讨新生儿缺血缺氧性脑病血钙水平的动态变化与病程和病情的关系。方法:将37例新生儿缺血缺氧性脑病分为轻、中、重三组,取股静脉血采用210型生化分析仪按OCPC法分别检测生后24 h、48 h、72 h、120 h、144 h血钙值。结果:新生儿缺血缺氧性脑病生后24 h内血钙开始下降;以生后48~72 h下降明显;72 h后血钙逐步开始回升;120~140h血钙大部分恢复正常。24 h内轻度、中度和中度、重度之间血钙对比无显著性意义,但轻度与重度之间对比有显著性意义;48~72 h轻中重度三组之间对比均有显著性意义,120~144 h轻度、中度和中、重度之间血钙对比无显著性意义,但轻度与重度之间血钙对比仍有显著性意义。结论:新生儿缺血缺氧性脑病血钙的变化与病程和病情密切相关,缺氧时间越长、程度越重,血管下降越明显。
Objective: To investigate the relationship between the dynamic changes of blood calcium level and the course and condition of neonatal hypoxic-ischemic encephalopathy. Methods: Thirty-seven neonates with hypoxic-ischemic encephalopathy were divided into three groups: light, medium and heavy. Blood samples were taken from the femoral vein by OCPC method using 210 biochemical analyzer for 24 h, 48 h, 72 h, 120 h, 144 h serum calcium value. Results: The level of serum calcium began to decrease within 24 hours after neonatal hypoxic-ischemic encephalopathy. After 48-72 hours of birth, the serum calcium decreased significantly. After 72 hours, the level of serum calcium started to rise gradually. Most of the serum calcium returned to normal within 120-140 hours. There was no significant difference in serum calcium between mild, moderate and severe within 24 h, but there was significant difference between mild and severe Significant significance, 120 ~ 144 h mild, moderate and moderate serum calcium between no significant, but there is still significant difference between mild and severe serum calcium. CONCLUSION: The change of serum calcium in neonatal hypoxic-ischemic encephalopathy is closely related to the course of disease and illness. The longer the hypoxia time is, the more the degree is, the more obvious the blood vessel descends.