论文部分内容阅读
通过对已知的钾离子通道开放剂的研究和PARM法的计算 ,建立了一个具有较好预报能力的钾离子通道开放剂药效团模型 ,并对从结构骨架与模型训练集分子具有较大差异的新型钾离子通道开放剂进行了有效的预报。
By studying the known K + channel opener and PARM method, a pharmacophore model of K + channel opener with good prediction ability was established, and the model of K + Differences in the new K + channel opener for effective prediction.