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目的探讨美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊治疗溃疡性结肠炎的临床疗效。方法选择92例溃疡性结肠炎患者为研究对象,采用随机数表法将92例患者分为观察组与对照组,每组46例。对照组患者予以美沙拉嗪颗粒治疗,观察组采用美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊治疗。比较两组患者的临床效果、复发情况及治疗前后的指标变化。结果治疗后对照组总有效率为76.09%,显著低于观察组的95.65%,差异有统计学意义(P<0.05);治疗后观察组白细胞介素-8、肿瘤坏死因子-α及丙二醛水平均显著低于对照组,而超氧化物歧化酶水平高于对照组,差异有统计学意义(P<0.05);观察组治疗后复发率明显低于对照组,差异有统计学意义(P<0.05)。结论美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊治疗溃疡性结肠炎临床疗效显著,可明显改善患者的多项指标,且治愈后复发率较低。
Objective To investigate the clinical efficacy of mesalazine granules combined with Bacillus subtilis bivalent enteric-coated enteric-coated capsules in the treatment of ulcerative colitis. Methods Ninety-two patients with ulcerative colitis were selected as study objects. 92 patients were divided into observation group and control group using random number table method, with 46 cases in each group. Patients in the control group were treated with mesalazine granules, while those in the observation group were treated with mesalazine granules combined with B. subtilis viable enteric-coated enteric-coated capsules. The clinical effects, recurrence and changes of indicators before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the control group was 76.09%, which was significantly lower than that of the observation group (95.65%, P <0.05). After treatment, the levels of interleukin-8, tumor necrosis factor- Aldehyde levels were significantly lower than the control group, and superoxide dismutase levels were higher than the control group, the difference was statistically significant (P <0.05); the recurrence rate of the observation group after treatment was significantly lower than the control group, the difference was statistically significant P <0.05). Conclusion Mesalazine combined with Bacillus subtilis viable enteric-coated enteric-coated capsules has significant clinical efficacy in treating ulcerative colitis, which can significantly improve the multiple indicators of patients and has a low recurrence rate after curative treatment.