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目的系统评价银杏达莫注射液联合倍他司汀治疗椎基底动脉供血不足性眩晕的疗效和安全性。方法计算机检索Cochrane图书馆、Web of Science、Medline、Embase、中国期刊全文数据库、维普数据库、万方数据库、中国生物医学文献数据库,检索时限从建库截止2015年9月,对纳入的随机对照试验进行方法学质量评价,并用Rev Man 5.2软件进行Meta分析。结果共纳入6个随机对照试验,结果显示:银杏达莫联合倍他司汀注射液组优于倍他司汀注射液单用组,差异有统计学意义[RR=1.21,95%CI(1.08,1.35),P=0.000 7];银杏达莫联合倍他司汀注射液组优于银杏达莫注射液单用组,差异有统计学意义[RR=1.17,95%CI(1.05,1.31),P=0.006]。结论银杏达莫联合倍他司汀注射液治疗椎基底动脉供血不足性眩晕具有一定优势,但纳入试验质量均较低,该结论还需进一步验证。
Objective To evaluate the efficacy and safety of the combination of gingivaldam injection and betahistine in the treatment of Vertebrobasilar insufficiency vertigo. Methods We searched the Cochrane Library, Web of Science, Medline, Embase, Chinese Journal Full-text Database, VIP Database, Wanfang Database and China Biomedical Literature Database. The search period was from September, Methodological quality was assessed and Meta-analysis was performed using Rev Man 5.2 software. Results A total of 6 randomized controlled trials were included. The results showed that the combination of gingko dipivoxil and betahistine injection was superior to betamethasone injection alone (RR = 1.21, 95% CI, 1.08 , 1.35), P = 0.0007]. The combination of gingko dipivoxil and betaine injection was superior to gingsengmo injection alone, the difference was statistically significant [RR = 1.17, 95% CI (1.05, 1.31) , P = 0.006]. Conclusion Ginkgo biloba combined with Bethesting injection has some advantages in treating vertigo of vertebrobasilar insufficiency. However, the quality of inclusion is low, which needs further verification.