目的探讨孕妇血型抗体效价与新生儿溶血病的关系。方法对2 126名孕妇常规进行血型鉴定,对血型不合者进行免疫性抗体效价检测。结果在2 126名血型不合的孕妇中,IgG抗A(B)效价≥1∶64的354名,占17%,Rh(D)阴性孕妇45名,抗-D效价≥1∶8的3名,占6.67%,当孕妇抗D效价≥1∶8或IgG抗A(B)效价≥1∶64时,患新生儿溶血病的概率增高。结论孕妇产前进行血型鉴定和抗体效价的检测,能为新生儿溶血病的早预防、早诊断、早治疗提供可靠依据。 Objective To investigate the relationship between blood group antibody titers and hemolytic disease in newborn. Methods Blood samples were routinely identified in 2 126 pregnant women and immunoglobulin antibody titer was detected in patients with abnormal blood type. Results Among 2 126 pregnant women with incompatible blood type, 354 (1/16) IgG titer ≥1: 64, 17%, 45 Rh-negative pregnant women with anti-D titer≥1: 8 3, accounting for 6.67%, when pregnant women anti-D titers ≥ 1: 8 or IgG anti-A (B) titers ≥ 1: 64, the risk of hemolytic disease of the newborn increases. Conclusion Prenatal diagnosis of blood type and antibody titer in pregnant women can provide a reliable basis for early prevention, early diagnosis and early treatment of hemolytic disease in newborn.