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目的研究2型糖尿病标准饮食对凝血、纤溶系统的影响。方法对40例2型糖尿病患者测量体质指数,并于空腹和标准饮食后2h采血,分别测定空腹血糖(FBG)和餐后血糖(PBG)、空腹胰岛素(FINS)和餐后血胰岛素(PINS)、空腹凝血时间(FTT)和餐后凝血时间(PTT)、空腹凝血酶原时间(FPT)和餐后凝血酶原时间(PPT)、空腹部分激活的凝血活酶时间(FAPTT)和餐后部分激活的凝血活酶时间(PAPTT)、空腹纤维蛋白原(FFIB)和餐后纤维蛋白原(PFIB)及空腹D-二聚体(FD-D)和餐后D-二聚体(PD-D),对可能影响2型糖尿病患者餐后凝血、纤溶的因素进行回归分析。结果PBG犤(17.23±6.37)mmol/L犦、PINS犤(56.71±34.54)mmol/L犦较空腹犤FBG为(11.75±5.31)mmol/L、,FINS为(15.76±9.06)mmol/L犦时增高,P<0.001;PTT犤(13.78±1.70)s、PPT犤(11.98±1.14)s犦、PAPTT犤(31.67±3.49)s犦较空腹时犤FTT为(15.26±1.26)s、FPT为(13.27±1.21)s、FAPTT为(34.39±3.74)s犦缩短;PFIB犤(4.18±1.54)g/L犦、PD-D犤(1.50±1.18)mg/L犦与空腹犤FFIB(3.75±1.43)g/L、FD-D为(0.86±0.63)mg/L犦比较明显升高;多因素回归分析表明,PD-D与PBG、FD-D正相关。结论单纯饮食控制治疗的2型糖尿病患者进食引起凝血、纤溶系统的激活主要表现为血液高凝状态。餐后凝血、纤?
Objective To study the effects of type 2 diabetes standard diet on coagulation and fibrinolytic system. Methods Body mass index was measured in 40 patients with type 2 diabetes mellitus, and blood samples were collected 2h after fasting and standard diet. Fasting blood glucose (FBG) and postprandial blood glucose (PBG), fasting insulin (FINS) and postprandial blood insulin (PINS) , Fasting blood clotting time (FTT) and postprandial clotting time (PTT), fasting blood clotting time (FPT) and postprandial prothrombin time (PPT), fasting partially activated thromboplastin time (FAPTT) Activated thromboplastin time (PAPTT), fasting fibrinogen (FFIB) and postprandial fibrinogen (PFIB) and fasting D-dimer (FD-D) and postprandial D-dimer ), Regression analysis of factors that may affect postprandial coagulation and fibrinolysis in type 2 diabetic patients. Results FBG was (11.75 ± 5.31) mmol / L and FINS was (15.76 ± 9.06) mmol / L, P <0.05) in PBG group (17.23 ± 6.37 mmol / L PIN and PINS 犤 56.71 ± 34.54 mmol / L 犦(13.78 ± 1.70) s, PPT 犤 (11.98 ± 1.14) s 犦 and PAPTT 犤 (31.67 ± 3.49) s 犦 were significantly higher than those of fasting group (P <0.001) (13.27 ± 1.21) s, FAPTT was (34.39 ± 3.74) s 犦 shortening; PFIB 犤 (4.18 ± 1.54) g / L PD and PD-D 犤 (1.50 ± 1.18) mg / L 犦 and fasting 犤 FFIB 1.43) g / L, and FD-D was (0.86 ± 0.63) mg / L respectively. Multivariate regression analysis showed that PD-D was positively correlated with PBG and FD-D. Conclusions The activation of coagulation and fibrinolytic system in patients with type 2 diabetes mellitus treated with simple diet control mainly manifested as hypercoagulable state of blood. Postprandial coagulation, fiber?